THE PARADOX OF AKT -MTOR INTERACTIONS

The paradox of Akt -mTOR interactions

The serine threonine (ser/thr) protein kinase, Akt, is at the central hub of signaling pathways that regulates cell growth, differentiation and survival.The reciprocal relation that exists between the two activating phosphorylation sites of Akt, T308 and S473, and the two mTOR complexes, C1 and C2, forms the central controlling hub that regulates t

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Retrospective cross-sectional study examining the association between loneliness and unmet healthcare needs among middle-aged and older adults using the Canadian Longitudinal Study of Aging (CLSA)

Objectives Our primary objective was to estimate the association between loneliness and unmet healthcare needs and if the association changes when adjusted for demographic and health factors.Our secondary objective was to examine the associations by gender (men, women, gender diverse).Design, setting, participants Retrospective cross-sectional data

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